Total serum IgE levels among adults patients with intermittent and persistent allergic asthmas

  • Iris Rengganis Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Dirga S. Rambe Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Cleopas M. Rumende Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Murdani Abdullah Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Keywords: allergic asthma, intermittent asthma, persistent asthma, total serum IgE level
Abstract viewed: 2399 times
PDF downloaded: 928 times
HTML downloaded: 5561 times
EPUB downloaded: 155 times


Background: Obesity with knee osteoarthritis (OA) is related to chronic pain causing physical inactivity that leads to decreased cardiorespiratory endurance and quality of life. Aquatic and land-based exercises are effective in improving physical activity. The aim of this study is to compare between aquatic and land-based exercise to improve cardiorespiratory endurance and quality of life in obese patients with knee osteoarthritis.

Methods: A single-blind, randomized, controlled trial was conducted on thirty-three obese patients with knee OA who visited Obesity Clinic of Medical Rehabilitation Cipto Mangunkusumo Hospital, from October 2016 to January 2017, subjects were divided into aquatic or land-based exercise group. Aerobic and knee-strengthening exercises were given. Cardiorespiratory endurance was assessed using the Borg Scale, whereas both the BORG CR-10 and SF-36 questionnaires were used to assess quality of life.

Results: After intervention, there were significant improvements in the land-based exercise group in the rating of perceived exertion (p=0.02), role limitations due to physical health (p=0.024), role limitations due to emotional problems (p=0.041), energy/fatigue (p=0.016), and the decline in pain (p=0.049) parameters. While in the aquatic exercise, there were significant improvements in leg fatigue (p=0.016), energy/fatigue (p=0.025), emotional well-being (p<0.001), and general health (p=0.045) parameters. Despite this, there were no significant differences between two groups regarding cardiorespiratory endurance and quality of life.

Conclusion: This study found that patients could start aquatic exercise to reduce leg fatigue and enhance general health and energy. After that, exercise could be continued in land-based settings to improve cardiorespiratory endurance and quality of life.


Download data is not yet available.


  1. Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM, et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J. 2015;46(3):622–39.

  2. Global Initiative on Asthma (GINA) [Internet]. global strategy for asthma management and prevention. [updated 2015; cited 2017 May] Downloaded from:

  3. U.S. Department of Health and Human Services. The National Heart, Lung, and Blood Institute. Guidelines for the diagnosis and management of asthma-expert panel report 3. Bethesda: NHLBI Health Information Center; 2007.

  4. Schatz M, Rosenwasser L. The allergic asthma phenotype. J Allergy Clin Immunol Pract. 2014;2(6):645–8.

  5. Dullaers M, De Bruyne R, Ramadani F, Gould HJ, Gevaert P, Lambrecht BN. The who, where, and when of IgE in allergic airway disease. J Allergy Clin Immunol. 2012;129(3):635–45.

  6. Borish L, Chipps B, Deniz Y, Gujrathi S, Zheng B, Dolan CM, et al. Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol. 2005;95(3):247–53.

  7. Zetterström O, Johansson SG. IgE concentrations measured by PRIST® in serum of healthy adults and in patients with respiratory allergy. A diagnostic approach. Allergy. 1981;36(8):537–47.

  8. Woszczek G, Kowalski ML, Borowiec M. Association of asthma and total IgE levels with human leucocyte antigen–DR in patients with grass allergy. Eur Respir J. 2002;20(1):79–85.

  9. Barnes PJ, Adcock IM. How do corticosteroids work in asthma? Ann Intern Med. 2003;139(5 Pt 1):359–70.

  10. Matsui EC, Sampson HA, Bahnson HT, Gruchalla RS, Pongracic JA, Teach SJ, et al. Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma. Allergy. 2010;65(11):1414–22.

  11. Sandeep T, Roopakala MS, Silvia CR, Chandrashekara S, Rao M. Evaluation of serum immunoglobulin E levels in bronchial asthma. Lung India. 2010;27(3):138–40.

  12. Chowdary VS, Vinaykumer EC, Rao JJ, Rao R, Babu KR, Rangamani V. A study on serum IgE and eosinophils in respiratory allergy patients. Indian J Allergy Asthma Immunol. 2003;17(1):21–4.

  13. Shin HD, Kim LH, Park BL, Jung JH, Kim JY, Chung IY, et al. Association of Eotaxin gene family with asthma and serum total IgE. Hum Mol Gen. 2003;12(11):1279–85.

  14. Al-Amri M, Al Rawas OA, Al Riyami BM, Richens ER. Atopy in Omani patients with asthma. J Sci Res Med Sci. 2002;4(1–2):15–23.

  15. Chung KF. Neutrophilic asthma: a distinct target for treatment? Lancet Respir Med. 2016;4(10):765–67.

  16. Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc. 2009;6(3):256–9.

  17. Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Non-eosinophilic corticosteroid unresponsive asthma. Lancet. 1999;353(9171):2213–14.

  18. Chang ML, Ciu C, Liu YH, Pei LC, Shao B. Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomed Rep. 2015;3(4):573–7.

  19. Bell RG. IgE, allergies and helminth parasites: a new perspective on an old conundrum. Immunol Cell Biol. 1996;74(4):337–45.

  20. Platts-Mills TA. The role of immunoglobulin E in allergy and asthma. Am J Respir Crit Care Med. 2001;164(8 Pt 2):S1–5.

  21. Anupama N, Sharma MV, Nagaraja HS, Bhat MR. The serum immunoglobulin e level reflects the severity of bronchial asthma. Thai J Physiol Sci. 2005;18(3):35–40.

  22. Dávila I, Valero A, Entrenas LM, Valveny N, Herráez L, SIGE Study Group. Relationship between serum total IgE and disease severity in patients with allergic asthma in Spain. J Investig Allergol Clin Immunol. 2015;25(2):120–7.

How to Cite
Rengganis I, Rambe DS, Rumende CM, Abdullah M. Total serum IgE levels among adults patients with intermittent and persistent allergic asthmas. Med J Indones [Internet]. 2018Dec.31 [cited 2024Jun.20];27(4):279-83. Available from:
Clinical Research

Most read articles by the same author(s)