Progressive sperm motility is associated with spontaneous pregnancy after varicocelectomy

  • Gede W.K. Duarsa Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah Hospital, Denpasar
  • I Komang O. Krishna Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah Hospital, Denpasar
  • Pande M.W. Tirtayasa Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah Hospital, Denpasar
  • I Wayan Yudiana Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah Hospital, Denpasar
  • Kadek B. Santosa Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah Hospital, Denpasar
  • Tjokorda G.B. Mahadewa Postgraduate Programme, Faculty of Medicine, Universitas Udayana, Denpasar
  • Anak A.G. Oka Department of Surgery, Faculty of Medicine, Universitas Udayana, Sanglah Hospital, Denpasar
DOI: https://doi.org/10.13181/mji.v27i4.2636
Keywords: sperm motility, spontaneous pregnancy, varicocelectomy
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Abstract

Background: Varicocelectomy is performed on patients with clinical varicocele associated with abnormal sperm parameters. The goal of this procedure is to improve men's sperm parameters and pregnancy rates of their partners. The objective of our study was to assess the factors that were associated with spontaneous pregnancy in female partners after varicocelectomy.

Methods: A retrospective case-control study was conducted to review several factors that are associated with spontaneous pregnancy after varicocelectomy. The data were taken from medical records at Sanglah General Hospital and three private hospitals in Denpasar from January 2015 to June 2016. Case subjects (n=38) include varicocele patients with abnormal sperm parameters whose partner had a spontaneous pregnancy following varicocelectomy and a control group (n=38) whose partner did not have a spontaneous pregnancy following varicocelectomy.

Results: Progressive sperm motility (≥37.5%) before varicocelectomy was 2.7 times more likely to result in a spontaneous pregnancy (odds ratio: 2.7; 95% confidence interval: 1.04–6.96; p=0.04). No statistical significance was found between age at varicocelectomy, grade of varicocele, body mass index, infertility duration, smoking habit, sperm concentration, normal sperm morphology before varicocelectomy, and spontaneous pregnancy.

Conclusion: Progressive sperm motility before varicocelectomy is a significant factor for the occurrence of spontaneous pregnancy after varicocelectomy.

References

  1. Baazeem A, Belzile E, Ciampi A, Dohle G, Jarvi K, Salonia A, et al. Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur Urol. 2011;60(4):796–808. https://doi.org/10.1016/j.eururo.2011.06.018

  2. Reddy SV, Shaik AB, Sailaja S, Venkataramanaiah M. Outcome of varicocelectomy with different degrees of clinical varicocele in infertile male. Adv Androl. 2015;2015:432950. http://dx.doi.org/10.1155/2015/432950

  3. Miyaoka R, Esteves SC. A critical appraisal on the role of varicocele in male infertility. Adv Urol. 2012;2012:597495. https://doi.org/10.1155/2012/597495

  4. Shridharani A, Owen R, Elkelany OO, Kim ED. The significance of clinical practice guidelines on adult varicocele detection and management. Asian J Androl. 2016;18(2):269–75. https://doi.org/10.4103/1008-682X.172641

  5. Kumar R, Sekar H, Krishnamoorthy S, Kumaresan N, Ramanan V. Analysis of outcomes of surgical treatment for varicocele in primary infertility based on seminal parameters and pregnancy rate. IJSS. 2016;4(4):205–10. https://doi.org/10.17354/ijss/2016/407

  6. Hosseini K, Nejatifar M, Kabir A. Comparison of the efficacy and safety of Palomo, Ivanissevich and laparoscopic varicocelectomy in Iranian infertile men with palpable varicocele. Int J Fertil Steril. 2018;12(1):81–7. https://doi.org/10.22074/ijfs.2018.5158

  7. Yuan R, Zhuo H, Cao D, Wei Q. Efficacy and safety of varicocelectomies: a meta-analysis. Syst Biol Reprod Med. 2017;63(2):120–9. https://doi.org/10.1080/19396368.2016.1265161

  8. Ding H, Tian J, Du W, Zhang L, Wang H, Wang Z. Open non-microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta-analysis of randomized controlled trials. BJU Int. 2012;110(10):1536–42. https://doi.org/10.1111/j.1464-410X.2012.11093.x

  9. Reşorlu B, Kara C, Sahin E, Unsal A. The significance of age on success of surgery for patients with varicocele. Int Urol Nephrol. 2010;42(2):351–6. https://doi.org/10.1007/s11255-009-9589-y

  10. Liguori G, Ollandini G, Pomara G, Amodeo A, Bertolotto M, Mazzon G, et al. Role of renospermatic basal reflow and age on semen quality improvement after sclerotization of varicocele. Urology. 2010;75(5):1074–8. https://doi.org/10.1016/j.urology.2009.10.068

  11. Duarsa GWK. Varikokel. In: Duarsa, GWK. Guidelines of Male Infertility. Jakarta: Ikatan Ahli Urologi Indonesia; 2015. p. 33–5. Indonesian.

  12. Abdalla A, Amin A, Hamdy A, Nady M. Spontaneous pregnancy outcome after surgical repair of clinically palpable varicocele in young men with abnormal semen analysis. Afr J Urol. 2011;17(4):115–21.

  13. Simforoosh N, Ziaee SA, Behjati S, Beygi FM, Arianpoor A, Abdi H. Laparoscopic management of varicocele using bipolar cautery versus open high ligation technique: a randomized, clinical trial. J Laparoendosc Adv Surg Tech A. 2007;17(6):743–7. https://doi.org/10.1089/lap.2006.0174

  14. Abdel-Meguid T, Al-Sayyad A, Tayib A, Farsi HM. Does varicocele repair improve male infertility? an evidence-based perspective from a randomized, controlled trial. Eur Urol. 2011;59(3):455–61. https://doi.org/10.1016/j.eururo.2010.12.008

  15. Gokce A, Demirtas A, Ozturk A, Sahin N, Ekmekcioglu O. Association of left varicocoele with height, body mass index and sperm counts in infertile men. Andrology. 2013;1(1):116–9. https://doi.org/10.1111/j.2047-2927.2012.00014.x

  16. Rais A, Zarka S, Derazne E, Tzur D, Calderon-Margalit R, Davidovitch N, et al. Varicocoele among 1 300 000 Israeli adolescent males: time trends and association with body mass index. Andrology. 2013;1(5):663–9. https://doi.org/10.1111/j.2047-2927.2013.00113.x

  17. Pham KN, Sandlow JI. The effect of body mass index on the outcomes of varicocelectomy. J Urol. 2012;187(1):219–21. https://doi.org/10.1016/j.juro.2011.09.033

  18. Zorba UO, Sanli OM, Tezer M, Erdemir F, Shavakhabov S, Kadioglu A. Effect of infertility duration on postvaricocelectomy sperm counts and pregnancy rates. Urology. 2009;73:767–71. https://doi.org/10.1016/j.urology.2008.06.014

  19. Collodel G, Capitani S, Iacoponi F, Federico MG, Pascarelli NA, Moretti E. Retrospective assessment of potential negative synergistic effects of varicocele and tobacco use on ultrastructural sperm morphology. Urology. 2009;74(4):794–9. https://doi.org/10.1016/j.urology.2009.01.078

  20. Fariello RM, Pariz JR, Spaine DM, Gozzo FC, Pilau EJ, Fraietta R, et al. Effect of smoking on the functional aspects of sperm and seminal plasma protein profiles in patients with varicocele. Hum Reprod. 2012;27(11):3140–9. https://doi.org/10.1093/humrep/des287

  21. Taha EA, Ezz-Aldin AM, Sayed SK, Ghandour NM, Mostafa T. Smoking influence on sperm vitality, DNA fragmentation, reactive oxygen species and zinc in oligoasthenoteratozoospermic men with varicocele. Andrologia. 2014;46(6):687–91. https://doi.org/10.1111/and.12136

  22. Peng J, Zhang Z, Cui W, Yuan Y, Song W, Gao B, et al. Spontaneous pregnancy rates in Chinese men undergoing microsurgical subinguinal varicocelectomy and possible preoperative factors affecting the outcomes. Fertil Steril. 2015;103(3):635–9. https://doi.org/10.1016/j.fertnstert.2014.12.091

  23. Shabana W, Teleb M, Dawod T, Elsayed E, Desoky E, Shahin A, et al. Predictors of improvement in semen parameters after varicocelectomy for male subfertility: a prospective study. Can Urol Assoc J. 2015;9(9–10):E579–82. https://doi.org/10.5489/cuaj.2808

  24. Björndahl L. The usefulness and significance of assessing rapidly progressive spermatozoa. Asian J Androl. 2010;12(1):33–5. https://doi.org/10.1038/aja.2008.50

  25. Al-Said S, Al-Naimi A, Al-Ansari A, Younis N, Shamsodini A, A-sadiq K, et al. Varicocelectomy for male infertility: a comparative study of open, laparoscopic and microsurgical approaches. J Urol. 2008;180(1):266–70. https://doi.org/10.1016/j.juro.2008.03.050

Published
2018-12-31
How to Cite
1.
Duarsa GW, Krishna IKO, Tirtayasa PM, Yudiana IW, Santosa KB, Mahadewa TG, Oka AA. Progressive sperm motility is associated with spontaneous pregnancy after varicocelectomy. Med J Indones [Internet]. 2018Dec.31 [cited 2024Apr.27];27(4):256-61. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/2636
Issue
Vol. 27 No. 4 (2018): December
Section
Clinical Research

Copyright (c) 2018 Gede W.K. Duarsa, I Komang O. Krishna, Pande M.W. Tirtayasa, I Wayan Yudiana, Kadek B. Santosa, Tjokorda G.B. Mahadewa, Anak A.G. Oka

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