A randomized clinical trial of freeze-dried amniotic membrane transplantation and conjunctival-limbal graft for pterygium excision and evaluation of conjunctival inflammation marker in tears

  • Made Susiyanti Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo-Kirana Hospital, Jakarta, Indonesia
  • Manoa Panjaitan Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo-Kirana Hospital, Jakarta, Indonesia
  • Grace Wangge Southeast Asian Ministers of Education Organization-Regional Center of Food and Nutrition (SEAMEO RECFON)/Pusat Kajian Gizi Regional Universitas Indonesia (PKGR UI), Jakarta, Indonesia https://orcid.org/0000-0002-5416-273X
  • Tjahjono Darminto Gondhowiardjo Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo-Kirana Hospital, Jakarta, Indonesia
DOI: https://doi.org/10.13181/mji.oa.203818
Keywords: amniotic membrane, interleukin-6, pterygium
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Abstract

BACKGROUND Minimizing inflammation on the ocular surface after pterygium surgery is essential to prevent recurrence. Currently, limited data are available for the comparison between freeze-dried amniotic membrane (FD-AM) and conjunctival–limbal graft (CLG). Therefore, this study aimed to assess conjunctival inflammation and the interleukin (IL)-6 levels in tears after pterygium excision between both techniques.

METHODS This prospective, single-blinded, randomized clinical trial included 26 eyes of 26 patients with primary or recurrent pterygium and who were indicated for pterygium surgery at Cipto Mangunkusumo Hospital, Indonesia from October 2017 until February 2018. The patients were scheduled for pterygium excision with FD-AM or CLG based on block randomization. Conjunctival inflammation and the level of IL-6 in tears were measured on day-7 and -28 after surgery.

RESULTS The 26 eyes (13 in each group) were subjected to a complete 1-month follow-up period. Day-7 after the surgery, severe inflammation occurred in 4/13 (31%) eyes having FD-AM and 8/13 eyes (62%) having CLG (p = 0.59). The IL-6 tear level increased similarly in FD-AM (22.85 pg/ml) and CLG (23.51 pg/ml) in (p = 0.78). No severe adverse events occurred.

CONCLUSIONS Pterygium excision using FD-AM yield a milder inflammation than CLG on day-7 and -28 after surgery. The tear IL-6 levels similarly increased on day-7.

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Published
2020-12-29
How to Cite
1.
Susiyanti M, Panjaitan M, Wangge G, Gondhowiardjo TD. A randomized clinical trial of freeze-dried amniotic membrane transplantation and conjunctival-limbal graft for pterygium excision and evaluation of conjunctival inflammation marker in tears. Med J Indones [Internet]. 2020Dec.29 [cited 2024Apr.26];29(4):359-65. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/3818
Issue
Vol. 29 No. 4 (2020): December
Section
Clinical Research

Copyright (c) 2020 Manoa Panjaitan, Grace Wangge, Tjahjono D. Gondhowiardjo, Made Susiyanti

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