Incretin-based therapies for type 2 diabetes mellitus in Asian patients: Analysis of clinical trials

  • Melva Louisa
  • Madoka Takeuchi
  • Masahiro Takeuchi
  • Nafrialdi Nafrialdi
  • Rianto Setiabudy
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Abstract

Aim To review the effi cacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population.

Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populations. Data pertinent to the efficacy and safety of GLP-1 mimetics and DPP-4 inhibitors were extracted and used.

Results We found 14 randomized controlled trials of incretin based-therapy which included 3567 type 2 diabetes mellitus in Asian population (Japanese, Chinese, Korean, Indian). It was shown that incretin-based therapies improved HbA1c at higher extent (up to -1.42% in exenatide 10 mcg bid, -1.85% for liraglutide 0.9 mg qd, -1.4% for sitagliptin 100 mg and -1.4% for vildagliptin 50 mg bid) compared to the effects observed in studies with Caucasian population, with comparable safety profile.

Conclusion The efficacy of incretin-based therapies in Asian patients improved glycemic parameters in a higher magnitude on some glycemic parameters compared with those in Caucasian population. These results indicate that incretin-based therapies may be more effective in Asian population than in Caucasian. (Med J Indones 2010; 19: 205-12)

Key words: exenatide, incretin, liraglutide, sitagliptin, type-2 diabetes, vildagliptin

Published
2010-08-01
How to Cite
1.
Louisa M, Takeuchi M, Takeuchi M, Nafrialdi N, Setiabudy R. Incretin-based therapies for type 2 diabetes mellitus in Asian patients: Analysis of clinical trials. Med J Indones [Internet]. 2010Aug.1 [cited 2020Jun.5];19(3):205-12. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/406
Section
Review Article

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