Schizonticidal effect of a combination of Amaranthus spinosus L. and Andrographis paniculata Burm. f./Nees extracts in Plasmodium berghei-infected mice

Authors

  • Tiwuk Susantiningsih
  • Rahmawati Ridwan
  • Ani R. Prijanti
  • Mohamad Sadikin
  • Hans-Joachim Freisleben

DOI:

https://doi.org/10.13181/mji.v21i2.482

Keywords:

Amaranthus spinosus, Andrographis paniculata, schizonticidal effect, Balb/c mice, Plasmodium berghei

Abstract

Background: Amaranthus spinosus and Andrographis paniculata are traditionally used as antimalarial herbs, but the combination of both has not yet been tested. The aim of this study was to determine the schizonticidal anti-malaria effect of a combination in Plasmodium berghei-infected mice.

Methods: Male mice (Balb/c strain) weighing 28-30 g, 7-8 weeks old, were randomly devided into 5 groups of 4 animals each. Group A: controls (nil) and 4 treatment groups (B, C, D, and E). Group B: Amarathus 10 mg/kgBW, group C: Andrographis 2 mg/kgBW, group D: combination of Amaranthus + Andrographis 10 mg + 2 mg/kgBW. All treatment with plant extracts was administered orally, once per day for 7 days. Group E was given chloroquine 10 mg/kgBW, once a day orally, for 3 days.

Results: The body weigh increased only in group D, hemoglobin concentration increased significantly vs controls (p < 0.05) in treatment groups C, D, and E, and blood schizonticidal activity was seen in all treatment groups, highest at almost 90% in groups D and E. Survival rate was 100% in all groups.

Conclusion: The combination of Amaranthus and Andrographis (10 mg + 2 mg/kgBW) exerts the same blood schizonticidal activity as chloroquine 10 mg/kgBW. (Med J Indones. 2012;21:66-70)

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Published

2012-05-01

How to Cite

1.
Susantiningsih T, Ridwan R, Prijanti AR, Sadikin M, Freisleben H-J. Schizonticidal effect of a combination of Amaranthus spinosus L. and Andrographis paniculata Burm. f./Nees extracts in Plasmodium berghei-infected mice. Med J Indones [Internet]. 2012May1 [cited 2024Dec.11];21(2):66-70. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/482

Issue

Section

Basic Medical Research
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