Food-induced brain activity in adult obesity: a quantitative electroencephalographic study
Abstract
BACKGROUND Obesity may be associated with declined food consumption control through neurological and behavioral processes, as well as heightened responsiveness of the brain’s reward systems. Performing neuroimaging and neurophysiological methods such as electroencephalography (EEG) can examine the connection between brain function and behavior. This study aimed to identify brain regulation of feeding behavior to food cues, which could be a potential neuromodulatory intervention target in adult obesity.
METHODS This cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Jakarta, involving 40 adults with obesity. EEG analysis was performed to measure electrophysiological brain activity during eyes-open condition and during exposure to high-calorie food cues. Student’s t-tests were performed to identify any significant differences between the groups (p<0.05).
RESULTS Beta waves in the frontal (channel F7) and gamma waves in the central (channels C3 and C4) and parietal (channels P3 and P4) regions were significantly increased during food cues compared to resting state/eyes-open condition without stimulation. Theta waves in the frontal (channels F7 and F8), central (channel C3), and parietal (channels P3 and P4) regions and alpha waves in the central (channels C3 and C4) and parietal (channels P3 and P4) regions were significantly decreased during food cues compared with resting state.
CONCLUSIONS In adults with obesity, increased beta activity in the frontal and gamma in the central and parietal regions suggested increased food-cue awareness and heightened attentional focus toward food stimuli. Additionally, decreased alpha and theta activities in frontal regions could underline deficits in executive functions and higher motivation.
References
Gadde KM, Martin CK, Berthoud HR, Heymsfield SB. Obesity: pathophysiology and management. J Am Coll Cardiol. 2018;71(1):69-84. https://doi.org/10.1016/j.jacc.2017.11.011
Health Research and Development Agency (Balitbangkes) Ministry of Health Republic of Indonesia. Basic health research (RISKESDAS 2018) [Internet]. Health Research and Development Agency (Balitbangkes) Ministry of Health Republic of Indonesia; 2018 [cited 2021 Aug 3]. Available from: http://www.depkes.go.id/resources/down load/info- terkini/materi_rakorpop_2018/Hasil%20 Riskesdas%202018.pdf.
Boswell RG, Kober H. Food cue reactivity and craving predict eating and weight gain: a meta-analytic review. Obes Rev. 2016;17(2):159-77. https://doi.org/10.1111/obr.12354
Davids S, Lauffer H, Thoms K, Jagdhuhn M, Hirschfeld H, Domin M, et al. Increased dorsolateral prefrontal cortex activation in obese children during observation of food stimuli. Int J Obes (Lond). 201;34(1):94-104. https://doi.org/10.1038/ijo.2009.193
Hume DJ, Howells FM, Rauch HG, Kroff J, Lambert EV. Electrophysiological indices of visual food cue-reactivity. Differences in obese, overweight and normal weight women. Appetite. 2015;85:126-37. https://doi.org/10.1016/j.appet.2014.11.012
World Health Organization (WHO). Waist circumference and waist-hip ratio: report of a WHO expert consultation, Geneva, 8-11 December 2008. World Health Organization (WHO); 2011. p. 3.
Kösling C, Schäfer L, Hübner C, Sebert C, Hilbert A, Schmidt R. Food-induced brain activity in children with overweight or obesity versus normal weight: an electroencephalographic pilot study. Brain Sci. 2022;12(12):1653. https://doi.org/10.3390/brainsci12121653
Samara A, Li X, Pivik RT, Badger TM, Ou X. Brain activation to high-calorie food images in healthy normal weight and obese children: a fMRI study. BMC Obes. 2018;5:31. https://doi.org/10.1186/s40608-018-0209-1
van Meer F, van der Laan LN, Charbonnier L, Viergever MA, Adan RA, Smeets PAet al,. Developmental differences in the brain response to unhealthy food cues: an fMRI study of children and adults. Am J Clin Nutr. 2016;104(6):1515-22. https://doi.org/10.3945/ajcn.116.137240
Yeo S, Kim KS, Lim S. Randomised clinical trial of five ear acupuncture points for the treatment of overweight people. Acupunct Med. 2014;32(2):132-8. https://doi.org/10.1136/acupmed-2013-010435
Centers for Disease Control and Prevention (CDC). National Health and Nutrition Examination Survey (NHANES): anthropometry procedures manual. Centers for Disease Control and Prevention (CDC); 2007.
World Health Organization (WHO) Regional Office for the Western Pacific. The Asia-Pacific perspective: redefining obesity and its treatment. Sydney: Health Communications Australia; 2000.
Tammela LI, Pääkkönen A, Karhunen LJ, Karhu J, Uusitupa MI, Kuikka JT. Brain electrical activity during food presentation in obese binge-eating women. Clin Physiol Funct Imaging. 2010;30(2):135-40. https://doi.org/10.1111/j.1475-097X.2009.00916.x
Hume DJ, Howells FM, Karpul D, Rauch HG, Kroff J, Lambert EV. Cognitive control over visual food cue saliency is greater in reduced-overweight/obese but not in weight relapsed women: An EEG study. Eat Behav. 2015;19:76-80. https://doi.org/10.1016/j.eatbeh.2015.06.013
Imperatori C, Fabbricatore M, Innamorati M, Farina B, Quintiliani MI, Lamis DA, et al. Modification of EEG functional connectivity and EEG power spectra in overweight and obese patients with food addiction: an eLORETA study. Brain Imaging Behav. 2015;9(4):703-16. https://doi.org/10.1007/s11682-014-9324-x
Blume M, Schmidt R, Hilbert A. Abnormalities in the EEG power spectrum in bulimia nervosa, binge-eating disorder, and obesity: a systematic review. Eur Eat Disord Rev. 2019;27(2):124-36. https://doi.org/10.1002/erv.2654
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