A double-blind randomized controlled trial of topical <em>Curcuma xanthorrhiza</em> Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions

Authors

  • Githa Rahmayunita Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
  • Tjut N.A. Jacoeb Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
  • Endi Novianto Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
  • Wresti Indriatmi Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Rahadi Rihatmadja Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology
  • Erdina H.D. Pusponegoro Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital. Indonesian Psoriasis Study Group, Indonesian Society of Dermatology and Venereology

DOI:

https://doi.org/10.13181/mji.v27i3.2511

Keywords:

topical Curcuma xanthorrhiza, psoriasis, PASI, Trozak score K6 expressions

Abstract

Background: Curcuma xanthorrhiza Roxb. exerts its anti-inflammatory effects by reducing the concentration of IL-6, IL-8, and phosphorylase kinase, which has role in keratinocyte proliferation. Our study aimed to evaluate the efficacy of C. xanthorrhiza in psoriasis.

Methods: From 18 to 59 year-old patients with mild psoriasis, 2 similar lesions were selected. The severity assessment was based on the psoriasis area severity index (PASI), Trozak score, and K6 expression. Using a double-blinded randomized method, lesion was treated with 1% C. xanthorrhiza ointment vs placebo for 4 weeks. The results were analyzed by the chi-square test using STATATM V.12 software (Stata Corp.).

Results: The study was conducted in 2010 to 2012 with 17 subjects participated. The median of PASI score were reduced significantly in both lesions, either treated with 1% C. xanthorrhiza ointment vs placebo; however when compared between the group, it was not significant (p=0.520). The Trozak score were reduced in lesions treated with 1% C. xanthorrhiza ointment; but it was not significant (p = 0.306). In lesions treated with placebo, the Trozak score was increased significantly. The difference of Trozak score between lesions treated with C. xanthorrhiza and placebo was significant (p=0.024). There was no significant difference of K6 expression in lesions treated with 1% C. xanthorrhiza ointments or placebo as well as on the difference of mean values of K6 expression between the group (p=0.827).

Conclusion: Based on the results, 1% C. xanthorrhiza ointment is effective treatment option for mild psoriasis, but longer follow-up period is suggested to confirm this results. C. xanthorrhiza ointment is safe for topical administration as there were no side effects reported in this study.

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Published

2018-10-12

How to Cite

1.
Rahmayunita G, Jacoeb TN, Novianto E, Indriatmi W, Rihatmadja R, Pusponegoro EH. A double-blind randomized controlled trial of topical &lt;em&gt;Curcuma xanthorrhiza&lt;/em&gt; Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions. Med J Indones [Internet]. 2018Oct.12 [cited 2024Dec.6];27(3):178-84. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/2511

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Clinical Research
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