A randomized control trial of platelet-rich plasma in supporting the recovery of postpartum levator ani muscle trauma

  • Fernandi Moegni Doctoral Programme in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia https://orcid.org/0000-0001-9537-4256
  • Andhika Rachman Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Ermita Ibrahim Ilyas Department of Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Alida Harahap Doctoral Programme in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Trika Irianta Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
  • Ferry Hidayat Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Dwiana Ocviyanti Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Budi Iman Santoso Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
DOI: https://doi.org/10.13181/mji.oa.226115
Keywords: obstetric labor complication, parturition, pelvic floor disorder, platelet-rich plasma, randomized controlled trial
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Abstract

BACKGROUND Pelvic floor dysfunction (PFD) is mostly caused by childbirth levator ani muscle (LAM) trauma. We hypothesized that platelet-rich plasma (PRP) therapy could support the recovery of LAM in postpartum trauma.

METHODS A prospective, single-blind, randomized control study was enrolled in primigravid women from November 2016 to July 2019 at 21 health facilities in Jakarta, Indonesia. Subjects were injected with autologous PRP or placebo at LAM during perineorrhaphy after childbirth. The primary outcome was regaining LAM strength and reducing levator hiatal area at 3 months postpartum. The LAM strength was examined by perineometer (cmH₂O), and levator hiatal area was examined by transperineal ultrasound (cm²) at antenatal and 3 months after delivery. Mann–Whitney U test and Wilcoxon signed-rank test were used for analysis. The study was registered in clinicaltrials.gov: NCT03021954.

RESULTS Among 240 women, 58 were eligible for analysis. There were no differences in LAM strength and levator ani hiatal area at 3 months postpartum between the two groups (p = 0.583 and p = 0.185, respectively).

CONCLUSIONS PRP therapy did not show a difference in the muscle recovery healing process.

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Published
2022-12-22
How to Cite
1.
Moegni F, Rachman A, Ilyas EI, Harahap A, Irianta T, Hidayat F, Ocviyanti D, Santoso BI. A randomized control trial of platelet-rich plasma in supporting the recovery of postpartum levator ani muscle trauma. Med J Indones [Internet]. 2022Dec.22 [cited 2024Jul.3];31(3):186-92. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/6115
Issue
Vol. 31 No. 3 (2022): September
Section
Clinical Research

Copyright (c) 2022 Fernandi Moegni, Andhika Rachman, Ermita Ibrahim Ilyas, Alida Harahap, Trika Irianta, Ferry Hidayat, Dwiana Ocviyanti, Budi Iman Santoso

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