The effects of phytosterol in low fat milk on serum lipid levels among mild-moderately hypercholesterolemic subjects
One of the most important risk factors for CHD is dyslipidemia, among others hypercholesterolemia or high LDL-cholesterol. Plant-sterols or phytosterols (PS) are among dietary factors known to lower blood cholesterol as part of therapeutic life-style changes diet. This study was aimed to evaluate the effect of PS properly solubilized in a-partly vegetable oil-filled low fat milk, on serum lipid levels in mild-moderate hypercholesterolemic subjects. Randomized, two-arm parallel control group trial was conducted at Department of Nutrition-University of Indonesia in Jakarta from June to November 2006. Each subject was randomly assigned to receive dietary life-style changes counseling plus 1.2 g phytosterol/day in low-fat milk (PS-group) or control group receiving the counseling alone for six weeks period. There were no significant changes of serum total and LDL-cholesterol of control group after a six week of dietary counseling (respectively 218.3 Â± 18.6 mg/dL to 219.6 Â± 24.3 mg/dL and 164.7Â±21.8 mg/dL to 160.0Â±26.4 mg/dL). There were a significant decreases of serum total and LDL-cholesterol (respectively p=0.01 and p=0.004) among subjects receiving PS after a six weeks observation period (respectively 233.5Â±24.6 mg/dL to 211.2Â±30.3 mg/dL and 176.9Â±24.7 mg/dL to 154.5Â±24.3 mg/dL). There was a significant difference in the LDL-lowering effects (p=0.024) among the PS-group after a six weeks (22.4Â±27.9 mg/dL) as compared to the control group (4.7Â±17.2 mg/dL). No significant changes were found on serum HDL-cholesterol and triglyceride levels in both groups. Although there was no significant difference found in daily nutrients intake between the-2 groups, however, significant reductions in body weight, body mass index and waist circumference were found only in the PS group (p=0.000; 0.000; 0.003, respectively). It is concluded that the lowering of total and LDL-cholesterol in those receiving life-style changes counseling plus 1.2 g PS daily for six weeks was significantly higher as compared to those of receiving counseling alone. (Med J Indones 2008; 17: 5-12)
Keywords: TLC Diet, LDL-cholesterol, HDL-cholesterol, triglyceride, phytosterol, body mass index, waist-circumference
Copyright (c) 2008 Sri Sukmaniah, Saptawati Bardosono, Samuel Oetoro, Inge Permadhi, Leilani Lestarina
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